Effect of granulocyte colony-stimulating factor combination therapy on efficacy of posaconazole (SCH56592) in an inhalation model of murine pulmonary aspergillosis.

نویسندگان

  • Andriani C Patera
  • Frederick Menzel
  • Craig Jackson
  • Joan K Brieland
  • Judy Halpern
  • Roberta Hare
  • Anthony Cacciapuoti
  • David Loebenberg
چکیده

Using an inhalation model of pulmonary aspergillosis, we observed modest differences in the survival rates of mice treated with granulocyte colony-stimulating factor (G-CSF) and posaconazole (POS) and those treated with POS alone. This finding is in contrast to a previous report that suggested that G-CSF had a significant antagonistic effect on the antifungal activity of POS.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 48 8  شماره 

صفحات  -

تاریخ انتشار 2004